NorthernBUG 2
- Date: 14th September 2018
- Location: The University of Sheffield
- Hosts: Mark Dunning, Matthew Parker, Dennis Wang
General
The Sheffield Bioinformatics Core are excited to host the 2nd NorthernBUG meeting at The Sheffield Institute for Translational Neuroscience on Friday September 14th 2018.
Agenda
| Time | Speaker | Presentation | Information |
|---|---|---|---|
| 12:00-13:00 | All | Lunch | |
| 13:00-13:10 | Mark Dunning | Welcome and Introduction to Northern BUG | |
| 13:10-13:20 | Jacob Parker | Investigation into the tissue specific pathology of the autosomal recessive cerebellar ataxias | Chair: Matt Parker |
| 13:20-13:40 | Jamie Ellingford | Uncovering pathogenic non-coding genomic variation through the UK 100,000 genomes project | |
| 13:40-13:50 | Georgette Tanner | Simulation of Heterogeneous Tumour Genomes with HeteroGenesis and In Silico Whole Exome Sequencing | |
| 13:50-14:20 | Niall Beard | Elixr TeSS | |
| 14:20-14:30 | All | Discussion: Establishing a Northern Training Network | |
| 14:30-15:00 | All | Coffee | |
| 15:00-15:20 | Roy Chaudhuri | TraDIS and Dr Who? | Chair: Dennis Wang |
| 15:20-15:30 | Yura Grabovska | Molecular sub-grouping of Malignant Rhabdoid Tumours | |
| 15:30-16:00 | Chris Yau | Scalable Bayesian Boolean Tensor Factorisation for Single Cell Genomics | |
| 16:00-16:30 | All | Discussion: Meeting format, next venue, addressing gender balance | |
| 16:30-17:00 | All | Drinks | The Francis Newton - Clarkehouse Road , Sheffield S10 2LA |
Speakers
Invited
Scalable Bayesian Boolean Tensor Factorisation for Single Cell Genomics Abstract: Binary data are often treated as continuous measurements so that standard dimensionality reduction methods designed for continuous data can be applied. This results in ambiguous low-dimensional representations since the observations are binary but the reduced dimensional representation is continuous. An alternative in which the latent low-dimensional representation is itself binary maybe more desirable. We have developed a family of binary data dimensionality reduction techniques based on Boolean logic called Logical Factorisation Machines (LFMs). In this talk I will describe the family of LFMs, the properties that give rise to scalable computation and applications in single cell genomics for interpretable unravelling of latent expression pathways.
Accepted
- Jamie Ellingford, University of Manchester
Uncovering pathogenic non-coding genomic variation through the UK 100,000 genomes project
- Roy Chaudhuri, University of Sheffield
TraDIS and Dr Who?
Student
- Jacob Parker, University of Sheffield
Investigation into the tissue specific pathology of the autosomal recessive cerebellar ataxias
- Georgette Tanner, University of Leeds
Simulation of Heterogeneous Tumour Genomes with HeteroGenesis and In Silico Whole Exome Sequencing
- Yura Grabovska, University of Newcastle
Molecular sub-grouping of Malignant Rhabdoid Tumours
Registration
Registration is now closed. Please contact bioinformatics-core@sheffield.ac.uk to check for spaces
Location:
SiTRAN, University of Sheffield, 385a Glossop Rd, Sheffield S10 2HQ